Severe Acute Neurotoxicity Reflects Absolute Intra-Carotid 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Dose in Non-Human Primates.

S. A. Norris, H. C. B. White,A. Tanenbaum, E. L. Williams,C. Cruchaga,L. Tian, R. E. Schmidt,J. S. Perlmutter

JOURNAL OF NEUROSCIENCE METHODS（2022）

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摘要

•Absolute MPTP dose differed with acute recovery versus severe acute neurotoxicity.•Body weight and mean brain volume did not differ across outcome groups.•Absolute, over weight-based, dose improves risk estimation of severe neurotoxicity.•Histopathology supports neurotoxicity at higher absolute MPTP doses.•Absolute MPTP dose should be used for intra-carotid MPTP in non-human primates.

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关键词

MPTP,Neurotoxicity,Monkey,Striatum,Basal ganglia

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