Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer

ESMO Open(2021)

引用 8|浏览37
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摘要
•No data exist on safety of assisted reproductive techniques (ART) in BRCA-mutated breast cancer patients.•This study investigated outcomes of patients with a post-treatment pregnancy achieved through ART use or naturally.•2 (9.1%) and 40 (27.4%) patients in the ART and non-ART groups experienced a disease-free survival event.•This study provides encouraging safety data on ART use in BRCA-mutated breast cancer survivors.•ART is feasible when natural conception fails or when survivors opt for carrying out preimplantation genetic testing.
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关键词
BRCA,breast cancer,fertility,ART,pregnancy,survival
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