Electroacupuncture treatment ameliorated the long-term cognitive impairment via activating eNOS/NO pathway and related Aβ downregulation in sepsis-survivor mice

Guo Jun,Yue Yong,Liyue Lu,Hao Gao,Zhiyu Yin,Pan Wei,Long Sun,Wenqing Ruan,Yinghua Zou,Li He,Wei Song,Qiuyu Tong,Xiongbiao Wang,Yongqiang Wang,Jiangang Song

Physiology & Behavior（2022）

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摘要

•We find that repeated electroacupuncture is a new treatment to improved cognitive function in sepsis-survivor mice.•Electroacupuncture works through activating eNOS/NO signaling and related aβ downregulation.•Our study provides a possible therapeutic and theoretical basis for the clinical prevention and treatment of cognitive dysfunction of sepsis-survivors.

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关键词

electroacupuncture,nonacupoint EA,cecal ligation and puncture,endothelial nitric oxide,phospho-eNOS,amyloidβ–peptide,amyloid-βprecursor protein,β-site AβPP cleaving enzyme 1

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