CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer

Debbie O'Reilly,Tim Downing,Sana Kouba,Marie Potier-Cartereau,Declan J. McKenna,Christophe Vandier,Paul J. Buchanan

Cell Calcium（2022）

引用 6|浏览12

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摘要

•CaV1.3 is upregulated in prostate cancer during androgen deprivation therapy•Expression of short 170kDa isoform determines CaV1.3 function in PCa•Store operated calcium entry is enhanced through CaV1.3 under androgen deprivation•Androgen independent proliferation and survival is linked to CaV1.3 calcium entry•CaV1.3 represents a novel oncochannel linked to castrate resistant prostate cancer

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关键词

Prostate Cancer,Androgen Deprivation Therapy,CaV1.3,Store operated calcium entry,CACNA1D,Aberrant Intracellular Calcium,Abbreviations,Androgen Deprivation Therapy (ADT),Androgen Receptor (AR),Calcium (Ca2+),Calcium Channel Blocker (CCB),Castrate Resistant Prostate Cancer (CRPC),Cellular Invasion and Migration (CIM),Colony Formation Assay (CFA),Cytosolic Calcium (Cac2+),Glyceraldehyde 3-phosphate dehydrogenase (GAPDH),Immunofluorescence (IF),Intracellular Calcium (Cai2+),Log2 fold-change (LogFC),Multiple Comparison Test (MCT),Principal Components Analysis (PCA),Prostate Cancer (PCa),Quality Control (QC),Thapsigargin (Tg),Tumour Microarrays (TMA),siRNA CaV1.3 (SiCaV1.3),SiRNA Control (sictr),Short Tandem Array (STR),Store Operated Current (SOC),Store Operated Calcium Entry (SOCE),Voltage Gated Calcium Channels (VGCC)

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