Study On The Therapeutic Effects Of Salicylazosulfapyridine On Ulcerative Colitis In Rats

Objective: To explore the therapeutic effects of salicylazosulfapyridine (SASP) on rats with ulcerative colitis (UC). Methods: The UC rat model was induced by coloclysis with TNBS (trinitrobenzene sulfonic acid)/alcohol. Thirty male SD rats were randomly divided into sham group, model group and SASP group with 10 rats in each group. During the two-week drug treatment, the weights, the intestinal mucosal injuries and the inflammation levels of rats in three different groups were recorded. Results: Compared with the model group, the body weight losses of rats (P<0.05) caused by UC were significantly improved and the incidences of loose stools (P<0.05) were alleviated in the SASP group. SASP could improve the injuries and morphological pathology changes of the colon tissue of rats, including the decrease of colon index, ulcer ratio and the number of aberrant crypt foci (ACF). SASP could significantly lower the inflammatory reactions in colon mucosa and effectively control the inflammation (P<0.05). Conclusion: SASP can effectively relieve intestinal inflammatory reactions and have good effects on UC in rats.