Correlations Of Pokemon And Stathmin Expression To Prognosis Of Colorectal Gastrointestinal Stromal Tumor

Objective: To investigate the correlations of Pokemon and Stathmin expression to prognosis of colorectal gastrointestinal stromal tumor (CGIST). Methods: Between January 2006 and December 2015, the clinical pathological data and surgical specimens from 56 patients with CGIST, as well as the non-tumor colorectal specimens from 10 patients in the Quzhou People's Hospital were collected and analyzed. The expression of Pokemon and Stathmin in the CGIST tissues was determined with immunohistochemistry. The patients after surgery were followed by phone or outpatient visits and the correlations of Pokemon and Stathmin expression and risk grading in the CGISTs to the rated of disease-free survival (DFS) among patients were analyzed. Results: Among the 56 patients with CGISTs, their sex (P=0.817) and age (P=0.643) were not associated with the DFS rates. The differences in the DFS rates were statistically significant in the four risk subgroups (P=0.002), with the DFS rates lower in the patients with moderate or high risks than in those with low or extremely low risks. The positivity of Pokemon and Stathmin expression increased in the patients with colorectal stromal tumors versus those with normal colorectal tissues (P=0.002, P=0.004), with the positivity of Pokemon and Stathmin expression higher in the patients with moderate or high risks than in those with low or extremely low risks (P=0.000, P=0.000). The DFS rates were significantly different between the patients with positive Pokemon and Stathmin expression and those with negative expression (P=0.005,P=0.008),with the DFS rate of the positive patients lower than that of negative ones. The differences among the three subgroups (0-2, 3-6, 7-9 scores) had statistical significance (P=0.018, P=0.027), whereas the differences between the two subgroups (3-6, 7-9 scores) did not (P=0.123, P=0.435). The positivity of Pokemon and Stathmin expression was negatively related to patients' DFS rate (RR=6.065 and RR=3.823 respectively). Conclusion: Pokemon and Stathmin are factors influencing prognosis of CGISTs.