The Mechanism Of Caix In Tumor Therapy And Its Influence On Patient Prognosis

The carbonic anhydrase IX (CAIX) family (originally named MN/G250) is a type of zinc-containing metalloenzyme family of cell surface transmembrane protein v. Many studies worldwide have demonstrated that CAIX is a protease that rapidly converts CO2 and H2O into H+ and HCO3-. its main mechanism in cells is to act as a "proton pump" in similar cells to maintain the weak alkalinity and extracelltdar acidic microenvironment of tumour cells. The positive expression of CAIX protein can be detected in trimly tumours such as nasopharyngeal carcinoma, cervical cancer, breast cancer, rectal cancer and gastric cancer, and is related to the occurrence and development of the tumour as well as the therapeutic effect and prognosis of patients. Therefore, the mechanism of CAIX in rumour cells is described in this paper, and the relationship between the expression of CAIX in cells and tumour treatment and prognosis is also discussed.