Saa Patients Encountering Multiple Organ Failure And Severe Infections During Pretreatment Was Rescued With Haplo-Hsct And Unrelated Bmsc Infusion And Achieved Transplantation Success: A Case Report And Literature Review

Objective: This study aims to investigate the treatment strategy of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for patients with severe aplastic anemia (SAA) combined with severe complications. Methods: A patient with SAA was treated with haplo-HSCT combined with unrelated bone marrow-derived mesenchymal stem cell (BMSC) infusion. During the pre-treatment, the patient encountered multiple organ failures and severe infections, but was successfully rescued; and the transplantation was also successful. The data of this patient were analyzed and related literatures were reviewed. Result: A 31-year-old male patient with SAA was treated with haplo-HSCT combined with unrelated BMSC infusion. During pretreatment, the patient encountered sepsis, acute cardiac insufficiency, pulmonary infection, respiratory failure, peritonitis and renal insufficiency, but was successfully rescued; and the transplantation was successful. Conclusion: Haplo-HSCT combined with unrelated BMSC infusion has significant curative effect on SAA. When serious complications occur during the transplant process, patients should not be given up.