Probing The Association Between Hpv-Induced Cervical Lesions And Microflora In Vagina

Cervical intraepithelial neoplasia (CIN) and cervical cancer are main threatening contributors for women healthy. Human papilloma virus (HPV) infection is the primary factor for their occurrence and development. Vaginal flora, PH value and cleanliness play crucial role in the progress of cervical lesions. In this research, we found that vaginal micro-ecological imbalance was gradually increased along with the promoted lesion degree. The most serious vaginal micro-ecological imbalance was detected in cervical cancer group (P<0.01). Meanwhile, we also studied the micro-ecology characteristics in patients with or without HR-HPV infection before treatments. The results indicated that HPV infection was an important factor, which could influence the dynamic balance of vaginal microbe system (P<0.01). In addition, we investigated the relationships between HPV and mycoplasma/ chlamydia composition. Mycoplasma and chlamydia infection might be the reason for the infection persistent with high risk HPV (P<0.05). Based on the results above, we consider vaginal micro-ecological detection has the potential ability to predict the development of cervical lesion and evaluate the prognosis of lesions, which provide clinical guidance to HPV treatment. The results in this study would provide important information for further research.