Prognostic Role Of Corrected Calcium Levels In Renal Cell Carcinoma: A Systematic Review And Meta-Analysis

Several recent studies have demonstrated that corrected calcium levels may be closely associated with prognosis in patients with renal cell carcinoma (RCC). In the present study, we conducted a meta-analysis of all available studies in the English literature to assess the prognostic value of corrected calcium levels in patients with RCC. We searched online databases that included PubMed, Embase, and Web of Science, for information on corrected calcium and its association with the outcomes of RCC. A total of 13 studies that included 6,705 patients were analyzed. Elevated corrected calcium levels were associated with a lower overall survival (OS) (hazard ratio = 1.84; 95% confidence interval [CI] = 1.67-2.02; P < 0.001). Furthermore, the association of elevated corrected calcium levels with poor survival was significant even on sub-group analyses for different tumor types, analysis types, cut-off values, and ethnicity. In conclusion, elevated corrected calcium concentration is associated with poor prognosis in patients with RCC, and may be considered as a potential biomarker for assessing the prognosis of this disease.