Acute Effects Of Irradiation On Exocrine Pancreatic Secretion In The Pig

The effect of gamma irradiation were investigated in five fistulated pigs in the pancreatic duct. Sampling of pancreatic juice was carried out over a 3-day period prior to and for a 5-day period after exposure. Volume of pancreatic juice, total protein concentration and enzyme activities of trypsin, chymotrypsin, lipase and amylase were determined. The volume of pancreatic juice and total protein daily secreted decreased after irradiation and remained lower than the control value throughout the experimental period. Same results were obtained for total activities of pancreatic enzymes. On the other hand, specific activities of the 3 classes of enzymes did not show significant modifications after irradiation.