Synthesis Of A Potent Nae Inhibitor: Pevonedistat

Hirotaki Mizutani,Steven Langston,Stepan Vyskocil

COMPREHENSIVE ACCOUNTS OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT: FROM DISCOVERY TO LATE STAGE PROCESS DEVELOPMENT, VOL 2（2016）

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摘要

Pevonedistat (MLN-4924, TAK-924) is a first-in-class inhibitor of Nedd-8 activating enzyme (NAE) currently undergoing clinical evaluation in oncology. This chapter will discuss the identification of pevonedistat and describe the synthetic routes undertaken by discovery chemists to provide material for pre-clinical studies.

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