Immunopathology Of Drug And Toxin-Related Skin Reactions

The skin has an important role as a barrier, protecting the organism from its environment. Therefore, it participates significantly in several immunological processes, and this novel role is gradually revealed in recent studies. We overview the main components of the cutaneous immunological response, divided into contact and systemic antigen exposures. The major players of the immunopathological skin reactions are the keratinocytes, Langerhans cells and dermal dendritic cells. In addition, we discuss the use of animal models for exploring the complexity of these reactions.