Improving The Prediction Of Multi-Component Tablet Properties From Pure Component Parameters

Direct compaction tabletting, a widely used secondary downstream processing operation, has recently received significant research attention. Experimental data can be used to fit model parameters for the prediction of single-component tablet thickness and hardness with good agreement, and this has been done for two components (Avicel (R) PH-101 and Pharmatose (R) 50M). These pure component parameters have then been used to predict multicomponent tablet properties, with the use of novel modified parameter averaging calculations improving predictions. Furthermore, a relation has been developed to estimate the required gap between tablet press punch faces for multicomponent tablets based on the gaps required for pure components; a quick and efficient way to estimate the necessary equipment settings to generate the desired compaction forces is a useful tool.