Tnfsf13b Correlated With Poor Prognosis And Immune Infiltrates In Kirc: A Study Based On Tcga Data

TNFSF13B is highly expressed in RCC tissues and is closely related to tumor immune escape strategy. The purpose of this study was to investigate the prognostic value of TNFSF13B and immune infiltrates in KIRC, based on data obtained from TCGA. Gene expression profiles and clinical information were downloaded from the TCGA database. Overall survival and disease-free analysis of hub genes was performed using GEPIA. Differential-expression and pairwise difference maps of TNFSF13B were analyzed using R software (version 3.5.1). The Molecular Signatures Database (MSigDB) was performed by the GSEA. In addition, TIMER was used to explore correlation levels between gene expression and abundance of immune infiltrates. FYB expression was high in cancer tissues of KIRC, compared with normal tissues. KIRC patients with TNFSF13B alteration showed worse overall survival and worse disease-free survival. Univariate analysis revealed that age at diagnosis, grade, stage, T, N, M, and TNFSF13B were statistically significant factors for KIRC progression. However, T and TNFSF13B were not statistically significant, according to multivariate analysis. Moreover, KIRC with high TNFSF13B expression was shown to be more prone to progression and metastasis than KIRC with low TNFSF13B expression. In addition, signaling pathways of TNFSF13B activated in KIRC were mainly enriched in cytokine-cytokine receptor interaction, natural killer cell-mediated cytotoxicity, and antigen processing. Importantly, TNFSF13B expression showed a significant positive correlation with infiltrating levels of B-cells, macrophages, neutrophils, and dendritic cells.