Effects Of Solanine On The Proliferation And Growth Of Glioma Cells

The aim of this study was to investigate the effects and acidification mechanisms of solanine on the proliferation and growth of glioma cells. U251 and U87 cells were treated with different concentrations of solanine. Inhibition rates were detected by the CCK8 method. Migration and invasion were checked by wound healing and Transwell assays. Apoptosis and cell cycle were measured by flow cytometry. Expression levels of Kir4.1 protein were analyzed by Western blot. It was found that solanine can inhibit the migration, invasion, and proliferation of U251 and U87 cells. Solanine can also promote apoptosis positively of U251 and U87 cells. Solanine can prevent U251 and U87 cells from proliferation and growth, causing tumor cell apoptosis through making them stop at the S phase of cell cycle. Solanine led to intracellular pH changes of the cells. Solanine is a potential drug helping to kill tumors.