Systems Approaches to Map in Vivo RNA–Protein Interactions in Arabidopsis Thaliana
RNA Technologies(2018)
摘要
Proteins that specifically interact with mRNAs orchestrate mRNA processing steps all the way from transcription to decay. Thus, these RNA-binding proteins represent an important control mechanism to double check which proportion of nascent pre-mRNAs is ultimately available for translation into distinct proteins. Here, we discuss recent progress to obtain a systems-level understanding of in vivo RNA-protein interactions in the reference plant Arabidopsis thaliana using protein-centric and RNA-centric methods as well as combined protein binding site and structure probing.
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关键词
CLIP,iCLIP,mRNA interactome,RNA-binding protein,RNA immunoprecipitation,RNA-protein interaction
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