Genome-Directed Identification Of Novel, Immediately Druggable Targets In Uterine Serous Papillary Carcinoma (Uspc)

H. M. Hanauske-Abel,S. Singh, M. Hoque, S. Husain, A. R. Hanauske, P. Soteropoulos, B. M. Cracchiolo

GYNECOLOGIC ONCOLOGY（2020）

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摘要

Objective: Proteins whose function requires posttranslational hydroxylation (PTH) are pivotal for cancer biology. The purpose of our study was to establish expression of PTH-dependent proteins and their oxygenases in the genetically verified ARK1 culture model of uterine serous papillary carcinoma (USPC). This cancer is clinically notorious for limited treatment options and extraordinary lethality.

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关键词

uterine serous papillary carcinoma,druggable targets,genome-directed

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