Results Of A Flow Cytometry Assay Measuring Oxidative Stress Relief As A Predictor Of Immunomodulatory Drugs (Imids) Sensitivity In Myeloma

Introduction - IMIDs are critical in the treatment of multiple myeloma (MM). Unfortunately, many patients become resistant and this is a major challenge in MM therapy. IMID resistance can be caused by CRBN mutations (rarely) and by upregulation of specific antioxidative mechanisms. We hypothesized that measuring baseline antioxidative capacity might be a useful predictor of IMID sensitivity in the clinic.