Conjugate Addition Of Acetal-Derived Benzyl Radicals Generated From Low-Valent Titanium-Mediated C-O Bond Cleavage

A new method for the generation of benzyl radicals from acetals via low-valent titanium-mediated homolytic C-O bond cleavage is presented. The low cost and availability of the developed titanium reagent enable efficient access to alpha-alkoxy carbon radical species via the developed reaction.