Extracorporeal Cytokine Removal in Chimeric Antigen Receptor T-cell Therapy Associated Cytokine Release Syndrome in Patient with Acute Lymphoblastic Leukemia. Case Report

Antonina E. Shchekina,Gennadii M. Galstyan,Olga A. Gavrilina, Natalia M. Arapova, Svetlana Iu Bronyakina,Ekaterina S. Kotova,Vera V. Troitskaya,Elena N. Parovichnikova,Mikhail A. Maschan,Valerii G. Savchenko

Terapevtičeskij arhiv（2021）

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摘要

Сytokine release syndrome is the common complication of CAR-T therapy. We report a case of patient with B-cell acute lymphoblastic leukemia developing сytokine release syndrome with shock and multiple organ failure and requiring cytokine removal and hemodiafiltration. Remission of the disease was achieved after CAR-T therapy.

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关键词

CAR-T-cell therapy,cytokine release syndrome,cytokine adsorption

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