Modified polymer nanospheres – Characterization and their anti-amyloid activity to insulin amyloid aggregation

Zuzana Bednarikova,Iryna Antal,Martina Kubovcikova,Martina Koneracka,Vladimir Girman,Vlasta Zavisova,Zuzana Gazova

Journal of Magnetism and Magnetic Materials（2021）

引用 4|浏览7

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摘要

•Preparation of PLA nanospheres modified with BSA or magnetic nanoparticles.•Hydrodynamic size and zeta potential was controlled by the added amount of BSA.•Magnetic PLA nanospheres were superparamagnetic.•The strongest destroying effect on insulin fibrils has the smallest particles.•The best inhibitor of insulin fibrillation was magnetic PLA nanospheres.

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关键词

Polymer nanospheres,Polylactic acid,Amyloid aggregation,Insulin,Iron oxide nanoparticles

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