Synthesis Of Hydantoin Alkynes Through Palladium-Catalyzed Reaction, Antibacterial Evaluation, And Molecular Docking Studies

Novel 3-(3-(aryl)prop-2-yn-1-yl)-5,5-diphenylimidazolidine-2,4-diones were synthesized through the reaction of 5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione and aryl iodides in the presence of a palladium-copper catalytic in CH3CN at room temperature. All prepared compounds were examined against the two bacterial strains, Micrococcus luteus and Pseudomonas aeruginosa and subjected by molecular docking studies. The in silico study carried out to predict the conformation of the examined compounds recommended that these compounds could bind noticeably to key the residues at the active site of dihydropteroate synthase. The interactive, biochemical, and in silico studies were in concordance with each other.