Meta-Analysis For The Prediction Of Mortality Rates In A Pediatric Intensive Care Unit Using Different Scores: Prism-Iii/Iv, Pim-3, And Pelod-2

Introduction: The risk of mortality is higher in pediatric intensive care units (PICU). To prevent mortality in critically ill infants, optimal clinical management and risk stratification are required.

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Aims and Objectives: To assess the accuracy of PELOD-2, PIM-3, and PRISM-III/IV scores to predict outcomes in pediatric patients.

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Results: A total of 29 studies were included for quantitative synthesis in meta-analysis. PRISM-III/IV scoring showed pooled sensitivity of 0.78; 95% CI: 0.72-0.83 and pooled specificity of 0.75; 95% CI: 0.68-0.81 with 84% discrimination performance (SROC 0.84, 95% CI: 0.80-0.87). In the case of PIM-3, pooled sensivity 0.75; 95% CI 0.71-0.79 and pooled specificity 0.76; 95% CI 0.73-0.79 were observed with good discrimination power (SROC, 0.82, 95% CI 0.78-0.85). PELOD-2 scoring system had pooled sensitivity of 0.78 (95% CI: 0.71-0.83) and combined specificity of 0.75 (95% CI: 0.68-0.81), as well as good discriminating ability (SROC 0.83, 95% CI: 0.80-0.86) for mortality prediction in PICU patients.

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Conclusion: PRISM-III/IV, PIM-3, and PELOD-2 had good performance for mortality prediction in PICU but with low to moderate certainty of evidence. More well-designed studies are needed for the validation of the study results.