Performance And Optimisation Of Triple Quadrupole Icp-Ms For Accurate Measurement Of Uranium Isotopic Ratios

The performance characteristics of the Agilent 8900 triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS/MS) system were evaluated and optimised concerning stability in measurements of uranium isotopic ratios. Multiple measurement parameters were evaluated for the determination of U isotopic ratios in certified standard solutions containing U-233, U-235 and U-238. Large irregular biases during repeated measurements of U isotopic ratios were observed using two identical ICP-MS/MS instruments. Depending on the mass filter resolution settings, the accuracy of U isotopic ratios can deviate up to 100% from the certified reference value. These variations in U isotopic ratios are primarily recognised as irregular drifts in the mass calibration of the two mass filters. This mass calibration drift is dependent on the isotope mass with a more pronounced drift for heavier isotopes. In order to solve the problem the resolution settings were optimised for both mass filters, which resulted in considerable improvement in precision and accuracy. A precision of 0.07% (relative standard deviation) for long-term measurement of U-233/U-235 ratios was achieved. Mass bias corrected U isotopic ratios agree very well with certified reference values with overall relative deviations from reference values of 0.005% and 0.17% for the SQ mode and MS/MS mode, respectively. The impact of the first mass filter in the MS/MS mode has a significant effect on the mass bias discrimination process and hence the accuracy of U isotopic ratios.