Recapitulation Of Organ-Specific Breast Cancer Metastasis Using An Engineered Multi-Tissue Platform

The 5-year survival rates for metastatic breast cancer are stuck at <30%. The plateauing of progress suggests the need for improved, dynamic, 3D, and human models of this multi-tissue process. Breast cancer metastasis also tends to have a subtype dependent organotropism. Here we show that using a novel organs-on-a-chip platform we have been able to recapitulate the multiple stages of both multi-tissue and tissue-specific breast cancer metastasis for the first time in an entirely human in vitro model.