1279P the Prognostic Value of Chemotherapy-Induced Neutropenia (CIN) in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) in the Era of Chemoimmunotherapy (CIT)

CIN was shown to be associated with a small but significant survival benefit in advanced NSCLC patients treated with chemotherapy. Since neutrophils are a form of myeloid-derived suppressor cells, which negatively regulate the function of T effector cells currently perceived as the major target of immune checkpoint inhibitors, we hypothesized that even a single episode of neutropenia may trigger a long-lasting immune response and lead to extended overall survival (OS) benefits.