1838P Germline Mutations in Homologous Recombination Repair (HRR) Pathway in a Chinese Multi-Cancer Retrospective Analysis

Germline mutations of HRR genes have been proven to be associated with familial cancers. Recently, FDA has approved olaparib for adult patients (pts) with deleterious germline or somatic HRR gene-mutated metastatic castration-resistant prostate cancer. Here, we reported an analysis of germline mutations of HRR genes in a multi-cancer cohort for pts who might benefit from PARP inhibitors in clinical development.