An Efficient Construction of CF3-Substituted Spirooxindole-Fused Benzo[a]quinolizidines by a Three-Component Cyclization

Benzo[a]quinolizidine is a key subunit in numerous natural products and pharmaceuticals, and therefore its synthesis has received much attention in resent years. Described herein is a convenient three-component cyclization for the efficient construction of CF3-substituted spirooxindole-fused benzo[a]quinolizidines by using CF3-propiolate as a building block. This attractive protocol may find great synthetic utility since CF3-containing complex structures were installed by a one-step cyclization under mild conditions.