The Latest Research Progress Of M(6)A Modification And Its Writers, Erasers, Readers In Infertility: A Review

Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N-6-methyladenosine (m(6)A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by "Writer" m(6)A methyltransferase, removed by "Eraser" m(6)A demethylase, and recognized by the m(6)A binding protein, thereby, linking m(6)A modification with other mRNA pathways. At various stages of the life cycle, m(6)A modification plays an extremely important role in regulating mRNA splicing, processing, translation, as well as degradation, and is associated with gametogenesis and fertility for both sexes. Normal gametogenesis is a basic guarantee of fertility. Infertility leads to trauma, affects harmony in the family and seriously affects the quality of life. We review the roles and mechanisms of RNA m(6)A methylation modification in infertility and provide a potential target for infertility treatment, which can be used for drug development.