Adipocyte extracellular vesicles: rescuers of cardiac mitochondrial stress.
Trends in endocrinology and metabolism: TEM(2021)
摘要
Nutrient excess induces mitochondrial dysfunction, which participates in obesity-related complications. Obesity also associates with high cardiac oxidative stress, which contributes to myocardial dysfunction. Crewe et al. recently evidenced the pivotal role of adipocyte-derived extracellular vesicles (EVs) in cardiac oxidative stress responses and revealed their unexpected protective effect against ischemia/reperfusion injury.
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