AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection

Michele Spinicci,Alessio Mazzoni,Beatrice Borchi,Lucia Graziani,Marcello Mazzetti,Filippo Bartalesi,Annarita Botta,Marta Tilli,Filippo Pieralli,Marco Coppi,Nicla Giovacchini,Maria Grazia Colao,Riccardo Saccardi,Gian Maria Rossolini,Francesco Annunziato,Alessandro Bartoloni

EUROPEAN JOURNAL OF IMMUNOLOGY（2022）

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摘要

A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.

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COVID-19, HIV, CD4, immunocompromised, monoclonal, convalescent plasma

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