The role of tumor acidification in aggressiveness, cell dissemination and treatment resistance of oral squamous cell carcinoma

Bianca de Bem Prunes, Júlia Silveira Nunes,Viviane Palmeira da Silva,Natalia Koerich Laureano, Douglas Rodrigues Gonçalves,Ian Santana Machado,Silvia Barbosa,Marcelo Lazzaron Lamers,Pantelis Varvaki Rados,Ina Kurth,Jochen Hess,Adriana Jou,Fernanda Visioli

Life Sciences（2022）

引用 14|浏览10

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摘要

•Extracellular acidification is a hallmark of solid tumors.•Tumor acidosis acts as selective evolutionary pressure.•The acidic microenvironment hinder response to chemo- and radiotherapy treatment.•pH neutralization restores treatment response, however, increases cell migration.

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关键词

Oral cancer,Tumor acidosis,Cell proliferation,Cell migration,Chemoresistance,Radioresistance

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