Role of EZH2 in bone marrow mesenchymal stem cells and immune–cancer interactions

•The review article shows aspects of EZH2 regulation in immune cells in relation toninflammatory/malignant settings.•The review article shows EZH2 regulation on BMSC differentiation into osteogenic and adipogenic cell lineages.•The review article summarize the newly attributed role in modulating non-histone targets.•The review article provide overview of small molecule inhibitors used to target EZH2 (and/or EZH1).