Unraveling the mysteries of MYT1L: From reprogramming factor to multifaceted regulator of neuronal differentiation

Neuron（2021）

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摘要

In this issue of Neuron, Chen et al. (2021) generated a mouse model for haploinsufficiency of MYT1L. MYT1L is widely used in neuronal reprogramming, and de novo mutations have been linked to a neurodevelopmental syndrome. Extensive characterization in this study better delineates MYT1L's role in transcriptional regulation and neuronal differentiation.

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关键词

Myt1l,autism,intellectual disability,neuronal development,gene transcription

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