Pharmacological inhibition of translocon is sufficient to alleviate endoplasmic reticulum stress and improve Ca2+ handling and contractile recovery of stunned myocardium

Juan Ignacio Elio Mariángelo,Carlos Alfredo Valverde,Leticia Vittone,Matilde Said,Cecilia Mundiña-Weilenmann

European Journal of Pharmacology（2022）

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摘要

•Blocking ER Ca2+ depletion via translocon suppressed the I/R-induced ER stress.•ER Ca2+ leak contributes to Ca2+ mishandling and contractile impairment during I/R.•Translocon inhibition emerges as a target to face deleterious consequences of I/R.

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关键词

MYOCARDIAL ISCHEMIA/REPERFUSION,ENDOPLASMIC RETICULUM STRESS,TRANSLOCON

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