Glyphosate and AMPA exposure in relation to markers of biological aging in an adult population-based study
International Journal of Hygiene and Environmental Health(2022)
摘要
Background/Aim
Glyphosate, a broad-spectrum herbicide, and its main metabolite aminomethylphosphonic acid (AMPA) are persistent in the environment. Studies showed associations between glyphosate or AMPA exposure and several adverse cellular processes, including metabolic alterations and oxidative stress.
Objective
To determine the association between glyphosate and AMPA exposure and biomarkers of biological aging.
Methods
We examined glyphosate and AMPA exposure, mtDNA content and leukocyte telomere length in 181 adults, included in the third cycle of the Flemish Environment and Health Study (FLEHSIII). DNA was isolated from leukocytes and the relative mtDNA content and telomere length were determined using qPCR. Urinary glyphosate and AMPA concentrations were measured by Gas Chromatography-Tandem Mass Spectrometry (GC-MS-MS). We used multiple linear regression models to associate mtDNA content and leukocyte telomere length with glyphosate or AMPA exposure while adjusting for confounding variables.
Results
A doubling in urinary AMPA concentration was associated with 5.19% (95% CI: 0.49 to 10.11; p = 0.03) longer leukocyte telomere length, while no association was observed with urinary glyphosate concentration. No association between mtDNA content and urinary glyphosate nor AMPA levels was observed.
Conclusions
This study showed that AMPA exposure may be associated with telomere biology in adults.
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关键词
AHS,AMPA,BUND,FLEHS,G-EQUAS,GC-MS-MS,IARC,IQR,LLOQ,NHANES,PCB,POP,ROS
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