Generation of CRISPR-Cas9 edited human induced pluripotent stem cell line carrying FLNC exon skipping variant

Flavie Ader,Laetitia Duboscq-Bidot, Sibylle Marteau, Matthieu Hamlin,Pascale Richard,Vincent Fontaine,Eric Villard

Stem Cell Research（2022）

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摘要

•FLNC hiPSC line useable for cardiomyocytes differenciation and heart tissu production.•Isogenic pair of iPSc generated through CRISPR/Cas9 Non-Homologous End Joining.•Homozygous Exon skipping FLNC human iPSc model for cardiomyopathy.•Decreased amount of a short FLNC protein expressed in cardiomyocytes.

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