KLF4, negatively regulated by miR-7, suppresses osteoarthritis development via activating TGF-β1 signaling

Jin Li,Mengqing Jiang,Chengwei Xiong, Jienen Pan,Shaohua Jia,Yi Zhang,Junjie Zhang,Nanwei Xu,Xindie Zhou,Yong Huang

International Immunopharmacology（2022）

引用 14|浏览21

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摘要

•KLF4 was down-regulated in OA tissues.•KLF4 could prevent OA development.•KLF4 also activated TGF-β1 signaling pathway, thereby affecting OA progression.

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关键词

KLF4,miR-7,TGF-β1,Osteoarthritis,Chondrocyte

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