Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults

The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated. A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) x fasting plasma glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid >= 357 mu mol/L (6 mg/dl) for females and >= 417 mu mol/L (7 mg/dl) for males. Our study suggested that the TyG index was higher in patients with hyperuricemia than in those without (8.99 +/- 0.61, 8.70 +/- 0.59, p < .001). The prevalence of hyperuricemia in patients with the lowest (<= 8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (>= 9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (p < .05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent. In Conclusions, the TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.