Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers

Zachary L Skidmore,Jason Kunisaki,Yiing Lin,Kelsy C Cotto,Erica K Barnell,Jasreet Hundal,Kilannin Krysiak,Vincent Magrini,Lee Trani,Jason R Walker,Robert Fulton,Elizabeth Brunt,Christopher A Miller,Richard K Wilson,Elaine R Mardis,Malachi Griffith,William Chapman,Obi L Griffith

Cancer Genetics（2022）

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摘要

•Non-cirrhotic HCC genomically resembles cirrhotic HCC•Comprehensive genome- and transcriptome-wide profiling allows detection of novel structural variants, fusions, and undiagnosed viral infections•NR1H4 fusions may represent a novel mechanism for tumorigenesis in HCC•Non-cirrhotic HCC is characterized by genotoxic mutational signatures and dysregulated liver metabolism•Clinical history and comprehensive omic profiling incompletely explain underlying etiologies for non-cirrhotic HCC highlighting the need for further research

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CAP1,CAP2,CNV,FFPE,GMS,HBV,HCA,HCC,HCV,INDELs,LOH,LVSI,NAFLD,NASH,PSC,RNAseq,SNV,SV,WGS

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