Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics

Rajat Desikan,Pranesh Padmanabhan,Andrzej M. Kierzek,Piet H. van der Graaf

International Journal of Antimicrobial Agents（2022）

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摘要

•COVID-19 virus dynamics models capture disease trajectories across populations.•Models yield insights into heterogeneity of infection severity and immune responses.•QSP models allow optimization of immunomodulatory agents, antivirals, and vaccines.

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关键词

SARS-CoV-2,COVID-19,Antiviral therapeutics,Vaccines,Quantitative systems pharmacology,Viral dynamics models

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