A vibrational in vitro approach to evaluate the potential of monoolein nanoparticles as isofuranodiene carrier in MDA-MB 231 breast cancer cell line: New insights from Infrared and Raman microspectroscopies

Valentina Notarstefano,Michela Pisani,Massimo Bramucci,Luana Quassinti,Filippo Maggi,Lisa Vaccari,Marco Parlapiano,Elisabetta Giorgini,Paola Astolfi

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2022）

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摘要

•Isofuranodiene is a sesquiterpene with proved multiple anticancer activities.•Cancer cell uptake and availability of isofuranodiene-loaded monoolein is tested.•IR and Raman spectra highlight changes in nucleic acids and carbohydrates.•Spectral changes could be related to apoptosis and nucleic acid fragmentation.

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关键词

Isofuranodiene,Monoolein nanoparticles,MDA-MB 231 cells,Fourier Transform Infrared Microspectroscopy,Raman Microspectroscopy,Chemometrics

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