A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments

Luca Vincenzo Cappelli,Danilo Fiore,Jude M Phillip,Liron Yoffe,Filomena Di Giacomo,Yang Hu,Clarisse Kayembe,Michael Ginsberg,Lorena Consolino,José Gabriel Barcia Durán,Nahuel Zamponi,Ari Melnick,Francesco Boccalatte,Wayne Tam,Olivier Elemento, Sabina Chiaretti,Anna Guarini, Robin Foa,Leandro Cerchietti,Shahin Rafii

Blood（2021）

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摘要

Background. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with few innovative treatment options. This is also contributed by the lack of models capable of capturing the complexity of the tumor and its microenvironment.

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