The Glucocorticoid Receptor-Dependent Stress Response in Human Erythropoiesis Is BCL11A-Dependent

Lilian Varricchio,Eliza Geer,Fabrizio Martelli,Maria Mazzarini,Alister Funnell,James J Bieker,Thalia Papayannopoulou,Anna Rita Migliaccio

Blood（2021）

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摘要

Extrapolations from data in mouse models and from human erythroid cells expanded ex vivo with the glucocorticoid receptor (GR) agonist Dexamethasone (Dex), suggest that GR plays an important role in the regulation of stress erythropoiesis 1. However, the mechanistic details of stress erythropoiesis are still poorly understood.

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