Cancer Cell Inhibitory Autophosphorylation of RAF Kinase in vitro and in cells

Matthew Holderfield,1 Hanne Merritt,1 John Chan,1 Marco Wallroth,1 Laura Tandeske,1 Huili Zhai,2 John Tellew,3 Stephen Hardy,1 Mohammad Hekmat-Nejad,1 Darrin D. Stuart,1,* Frank McCormick,4 and Tobi E. Nagel1 1Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA 2Novartis Institutes for Biomedical Research, Cambridge, CA 02139, USA 3Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA 4Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA *Correspondence: darrin.stuart@novartis.com http://dx.doi.org/10.1016/j.ccr.2013.03.033