Hemophagocytic Lymphohistiocytosis/Macrophage-Activation Syndrome (HLH/MAS) Following Treatment with Tisagenlecleucel

Reyes Maria Martin-Rojas,Ignacio Gomez-Centurion,Rebeca Bailen,Mariana Bastos,Francisco Diaz-Crespo,Diego Carbonell,Rafael Correa-Rocha,Marjorie Pion,Cristina Muñoz,Milagros Sancho, Isabel Gomez-Fernandez,Gillen Oarbeascoa,Ana Perez-Corral,Carolina Martinez-Laperche,Javier Anguita,Ismael Buño,Javier Menarguez,Jose Luis Diez-Martin,Mi Kwon

CLINICAL CASE REPORTS（2021）

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摘要

CAR-T cell related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with high mortality rates and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR-T cell follow-up, allows a more precise management of this complication.

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关键词

CAR T cells, hemophagocytic lymphohistiocytosis, macrophage activation syndrome, tisagenlecleucel

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