0 Repurposing 18 F-FMISO as a PET tracer for translational imaging of 1 nitroreductase-based gene directed enzyme prodrug therapy . 2

Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Jonas Lies vei 65, N6 5021, Bergen, Norway; University Hospital 12 de Octubre, Madrid, Spain; Lung Cancer Unit H12O-CNIO, Spain 7 Department of Chemistry and Centre for Pharmacy, University of Bergen, Allégaten 41, N-5007, Bergen, Norway; 8 KinN Therapeutics AS, Jonas Lies vei 65, 5021 Bergen, Norway; Department of Pathology, Oslo University 9 Hospital, Norwegian Radium Hospital, and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, 10 Oslo, Norway. Molecular imaging Center, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N11 5009, Bergen, Norway; Western Norway University College, Inndalsveien 28, N-5063, Bergen, Norway; 12 Department of Pathology, Haukeland University Hospital, Jonas Lies vei 65, N-5021, Bergen, Norway; Centre for 13 Pharmacy, Department of Clinical Science, University of Bergen, Jonas Lies vei 65, Bergen 5021, Norway; 14 Vivarium, Department of Clinical Science, University of Bergen, Jonas Lies vei 65, 5021 Bergen, Norway. 15 16 These authors contributed equally to this work 17