Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy

Xiaoyan Guo,Qi Su, Tao Liu,Xiaoning He,Pingyun Yuan,Ran Tian,Bei Li,Yanmin Zhang,Xin Chen

Chemical Engineering Journal（2022）

引用 9|浏览15

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摘要

•Smart gold nanoparticles (AEPF) are synthesized for tumor therapy.•AEPF achieved Ca2+ regulation, mitochondrion disorder and photothermal therapy.•AEPF utilized tumor specific environments to perform accurate anti-tumor treatment.•AEPF manipulated tumorigenic environment to further enhance therapeutic efficiency.

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关键词

Intelligent Gold Nanoparticles,Accurate tumor treatment via chain activities,Esterase triggered intracellular Ca2+ regulation,Ca2+ dependent photothermal therapy,Utilization and manipulation of tumor-specific micro-environments

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