Multi-omics analysis of biomarkers and molecular mechanism of rheumatoid arthritis with bone destruction

Qian Huang,Jiang Su,Weihua Zhang, Shengjia Chang,Silin Li,Jun Zhou,Jie Zhang,Xue Li, Hong Huang,Tingting Wang,Xuejun Jiang,Jianhong Wu,Jing Zhu,Fanxin Zeng

Joint Bone Spine（2022）

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摘要

•Seven metabolites were selected for classifying the BD(+) and BD(−) groups with moderate accuracy (AUC=0.71).•The changed 4 bacteria and 12 fungi yielded accuracy (AUC=0.74 and AUC=0.87, respectively) for the two groups.•Nontargeted LC-MS, 16S rRNA, and ITS highlighted a novel link among the metabolites, bacteria, and fungi.

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关键词

Rheumatoid arthritis,Bone destruction,Metabolites,Bacteria,Fungi

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